Prof. Dr. rer. nat. habil. Hans-Peter Deigner

Hans-Peter Deigner
  • Fakultät Medical and Life Sciences
  • Villingen-Schwenningen Campus
  • Room B 2.06
  • Phone 07720 307-4232

Office hours

Sprechzeiten: nach Vereinbarung

Field of research and / or teaching

Lehrgebiete:

  • Biomarker 
  • Molekulare Diagnostik 
  • Metabolomics 
  • Biobanking 
  • Spezielle Aspekte der Systembiologie
     
  • Gastwissenschaftler Fraunhofer Gesellschaft, Institut für Zelltherapie und Immunologie (IZI), EXIM, Rostock
  • Gründungsmitglied und Mitglied des Exekutivkomitees der Europäischen Gesellschaft für Biopreservation und Biobanking (ESBB, www.esbb.org

Publications

Deigner, Hans-Peter

2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988

2023

Benjamin Brandes, Sophie Hoenke, Christian Schultz, Hans-Peter Deigner, Rene Csuk Converting bile acids into mitocans

2022

Max Borgolte, Isabel Quint, Lars Kaiser, Rene Csuk, Hans-Peter Deigner A Fluorescence-Based Competitive Antibody Binding Assay for Kynurenine, a Potential Biomarker of Kidney Transplant Failure
Axel Franz, Hacer Yapicioglu-Yildizdas, Erdal Taskin, Akan Yaman, Yalcin Celik, Huseyin Simsek, Serif Hamitoglu, Nesil Aydinol, Elif Keles, Matthias Keller, Manon Benders, Floris Groenendaal, Kim Anninck, Lena Hellström-Westas, Ola Saugstad, Neil Marlow, Hans-Peter Deigner, Matthias Kohl, Ron Meyer, Achim Plum, Carola Steins-Rang, Peter Bartmann Asphyxia Associated Metabolite Biomarker Investigation (AAMBI). Short-term clinical outcomes and at the age of 22 to 42 months
Marie Kozubek, Sophie Hoenke, Hans-Peter Deigner, Rene Csuk Betulinic acid and glycyrrhetinic acid derived piperazinyl spacered rhodamine B conjugates are highly cytotoxic and necrotic
Angelika Czajkowska, Defne I. Dayi, Helga Weinschrott, Hans-Peter Deigner, Magnus S. Schmidt Chemical decarboxylation kinetics and identification of amino acid standards by benchtop NMR spectroscopy
Jessica Jung, Lars Kaiser, Hans-Peter Deigner, Magnus S. Schmidt Continuous synthesis of bromoalkyl glycosides by Fischer glycosylation in a microreactor
Alexandra Zorin, Lukas Klenk, Tonia Mack, Hans-Peter Deigner, Magnus S. Schmidt Current Synthetic Approaches to the Synthesis of Carbasugars from Non-Carbohydrate Sources
Oliver Riester, Stefan Laufer, Hans-Peter Deigner Direct 3D printed biocompatible microfluidics: assessment of human mesenchymal stem cell differentiation and cytotoxic drug screening in a dynamic culture system
Toni C. Denner, Sophie Hoenke, Oliver Kraft, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk Hydroxyethylamide substituted triterpenoic acids hold good cytotoxicity for human tumor cells
Weronika Schary, Filip Paskali, Simone Rentschler, Christoph Ruppert, Gabriel E. Wagner, Ivo Steinmetz, Hans-Peter Deigner, Matthias Kohl Open-Source, Adaptable, All-in-One Smartphone-Based System for Quantitative Analysis of Point-of-Care Diagnostics
Markus Blaess, Oliver Sommerfeld, Rene Csuk, Hans-Peter Deigner Small molecules targeting endolysosomal acidification and signaling in sepsis and severe SARS-CoV-2 infection/COVID-19
Oliver Riester, Pia Burkhardtsmaier, Yuna Gurung, Stefan Laufer, Hans-Peter Deigner, Magnus S. Schmidt Synergy of R‑(–)carvone and cyclohexenone‑based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation
Benjamin Brandes, Sophie Hoenke, Niclas Starke, Immo Serbian, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk Synthesis and cytotoxicity of apoptosis-inducing N-heterocyclic triterpene amides
Marie Kozubek, Sophie Hoenke, Theresa Schmidt, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk Synthesis and cytotoxicity of betulin and betulinic acid derived 30-oxo-amides
Max Borgolte, Oliver Riester, Isabel Quint, Felix Blendinger, Volker Bucher, Stefan Laufer, Rene Csuk, Luca Scotti, Hans-Peter Deigner Synthesis of a biocompatible benzophenone-substituted chitosan hydrogel as novel coating for PEEK with extraordinary strong antibacterial and anti-biofilm properties
Niels V. Heise, Jördis-Ann Schüler, Torje E. Orlamünde, Benjamin Brandes, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk Triterpenoid cholinesterase inhibitors that might improve gait disturbances in Parkinson's disease patients
Susanne Jacksch, Christoph König, Dominik Kaiser, Lars Kaiser, Mirko Weide, Sylvia Schnell, Hans-Peter Deigner, Markus Egert Using OMICS-technologies to unravel the mystery of malodour formation in washing machines and on washed laundry

2021

Benjamin Brandes, Sophie Hoenke, Michael Türk, Björn Weber, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk A unified strategy for the synthesis of amorfrutins A and B and evaluation of their cytotoxicity
Marie Kozubek, Linda Höhlich, Sophie Hoenke, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk Apoptotic activity of substituted 3-O-acetyl-betulinic acid benzylamides
Abid A. Khan, Sana Khan, Suhaib Khan, Simone Rentschler, Stefan Laufer, Hans-Peter Deigner Biosynthesis of iron oxide magnetic nanoparticles using clinically isolated Pseudomonas aeruginosa
Oliver Riester, Max Borgolte, Rene Csuk, Hans-Peter Deigner Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution
Mostafa Mahmoud, Christoph Ruppert, Simone Rentschler, Stefan Laufer, Hans-Peter Deigner Combining aptamers and antibodies: lateral flow quantification for thrombin and interleukin-6 with smartphone readout
Theresa Schmidt, Niels Heise, Kurt Merzweiler, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk Concise Synthesis of Both Enantiomers of Pilocarpine
Saeb Aliwaini, Bassam Abu Thaher, Ihab Al-Masri, Nabil Shurrab, Said El-Kurdi, Dieter Schollmeyer, Basem Qeshta, Mariam Ghunaim, Rene Csuk, Stefan Laufer, Lars Kaiser, Hans-Peter Deigner Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents
Markus Blaess, Lars Kaiser, Oliver Sommerfeld, Rene Csuk, Hans-Peter Deigner Drug triggered pruritus, rash, papules, and blisters – is AGEP a clash of an altered sphingolipid-metabolism and lysosomotropism of drugs accumulating in the skin?
Markus Blaess, Lars Kaiser, Oliver Sommerfeld, Rene Csuk, Hans-Peter Deigner Drugs, Metabolites, and Lung Accumulating Small Lysosomotropic Molecules: Multiple Targeting Impedes SARS-CoV-2 Infection and Progress to COVID-19
Said El-Kurdi, Bassam Abu Thaher, Kanan Wahedy, Dieter Schollmeyer, Levin Nopper, Oliver Riester, Hans-Peter Deigner Efficient Synthesis and X-ray Structure of [1,2,4]Triazolo[4,3-a]pyridines via Oxidative Cyclization Using N-Chlorosuccinimide (NCS)
Simone Rentschler, Lars Kaiser, Hans-Peter Deigner Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
Teresa Schätzl, Lars Kaiser, Hans-Peter Deigner Facioscapulohumeral muscular dystrophy: genetics, gene activation and downstream signalling with regard to recent therapeutic approaches: an update
Lars Kaiser, Isabel Quint, Rene Csuk, Manfred Jung, Hans-Peter Deigner Lineage-Selective Disturbance of Early Human Hematopoietic Progenitor Cell Differentiation by the Commonly Used Plasticizer Di-2-ethylhexyl Phthalate via Reactive Oxygen Species: Fatty Acid Oxidation Makes the Difference
Max Borgolte, Oliver Riester, Tereza Kacerova, Simone Rentschler, Magnus S. Schmidt, Susanne Jacksch, Markus Egert, Stefan Laufer, Rene Csuk, Hans-Peter Deigner Methacryloyl-GlcNAc Derivatives Copolymerized with Dimethacrylamide as a Novel Antibacterial and Biocompatible Coating
Weronika Schary, Filip Paskali, Simone Rentschler, Christoph Ruppert, Gabriel Wagner, Ivo Steinmetz, Hans-Peter Deigner, Matthias Kohl Open-source, Adaptable, All-in-one Smartphone-based System for Quantitative Analysis of Point-of-care Diagnostics
Abid A. Khan, Khanzadi N. Manzoor, Aamir Sultan, Maria Saeed, Mahrukh Rafique, Sameen Noushad, Ayesha Talib, Simone Rentschler, Hans-Peter Deigner Pulling the Brakes on Fast and Furious Multiple Drug-Resistant (MDR) Bacteria
Nico Laur, Lars Kaiser, Hans-Peter Deigner, Ralf Kinscherf Sequential Analysis of Trace Elements in a Micro Volume Urine Sample Using Inductively Coupled Plasma Mass Spectrometry
Benjamin Brandes, Jan H. Halz, Kurt Merzweiler, Hans-Peter Deigner, Rene Csuk Synthesis and structure of azelastine-N-oxides
Alexander M. König, Ulrich Köhler, Olaf Hildebrandt, Hans Schwarzbach, Lena Hannemann, Raphael Boneberg, Johannes T. Heverhagen, Andreas H. Mahnken, Malte Keller, Peter H. Kann, Hans-Peter Deigner, Nico Laur, Ralf Kinscherf, Wulf Hildebrandt The Effect of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Therapy on Skeletal Muscle Lipid Content in Obese and Nonobese Men
Sophie Hoenke, Martin A. Christoph, Sander Friedrich, Niels Heise, Benjamin Brandes, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk The Presence of a Cyclohexyldiamine Moiety Confers Cytotoxicity to Pentacyclic Triterpenoids
Niels Heise, Sophie Hoenke, Vivienne Simon, Hans-Peter Deigner, Ahmed Al-Harrasi, Rene Csuk Type and position of linkage govern the cytotoxicity of oleanolic acid rhodamine B hybrids
Immo Serbian, Erik Prell, Claudia Fischer, Hans-Peter Deigner, Rene Csuk n-Propyl 6-amino-2,6-dideoxy-2,2-difluoro-β-D-glucopyranoside is a good inhibitor for the β-galactosidase from E. coli

2020

Sophie Hoenke, Niels V. Heise, Michael Kahnt, Hans-Peter Deigner, Rene Csuk Betulinic acid derived amides are highly cytotoxic, apoptotic and selective
Markus Blaess, Lars Kaiser, Martin Sauer, Rene Csuk, Hans-Peter Deigner COVID-19/SARS-CoV-2 Infection: Lysosomes and Lysosomotropism Implicate New Treatment Strategies and Personal Risks
Christoph Ruppert, Lars Kaiser, Lisa Jacob, Stefan Laufer, Matthias Kohl, Hans-Peter Deigner Duplex Shiny app quantification of the sepsis biomarkers C-reactive protein and interleukin-6 in a fast quantum dot labeled lateral flow assay
Nico Laur, Ralf Kinscherf, Karolina Pomytkin, Lars Kaiser, Otto Knes, Hans-Peter Deigner ICP-MS trace element analysis in serum and whole blood
Markus Bläss, Lars Kaiser, Martin Sauer, Hans-Peter Deigner Lysosomotropic Active Compounds — Hidden Protection against COVID-19 / SARS-CoV-2 Infection?
Lars Kaiser, Helga Weinschrott, Isabel Quint, Markus Blaess, Rene Csuk, Manfred Jung, Matthias Kohl, Hans-Peter Deigner Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways
Hans-Peter Deigner, Mostafa Mahmoud Method for the detection and quantification of small Molecules and Fluidic platform for performing the same
Sophie Hoenke, Immo Serbian, Hans-Peter Deigner, Rene Csuk Mitocanic Di- and Triterpenoid Rhodamine B Conjugates
Markus Blaess, Lars Kaiser, Oliver Sommerfeld, Simone Rentschler, Rene Csuk, Hans-Peter Deigner Rational Drug Repurposing: Focus on Lysosomotropism, Targets in Disease Process, Drug Profile, and Pulmonary Tissue Accumulation in SARS-CoV-2 Infection/COVID-19
Benjamin Brandes, Lukas Koch, Sophie Hoenke, Hans-Peter Deigner, Rene Csuk The presence of a cationic center is not alone decisive for the cytotoxicity of triterpene carboxylic acid amides

2019

Christoph Ruppert, Navneet Phogat, Stefan Laufer, Matthias Kohl, Hans-Peter Deigner A smartphone readout system for gold nanoparticle-based lateral flow assays: application to monitoring of digoxigenin
Mostafa Mahmoud, Stefan Laufer, Hans-Peter Deigner An aptamer based thermofluorimetric assay for ethanolamine
Mostafa Mahmoud, Stefan Laufer, Hans-Peter Deigner Data for homogeneous thermofluorimetric assays for ethanolamine using aptamers and a PCR instrument
Markus Blaess, Hans-Peter Deigner Derailed Ceramide Metabolism in Atopic Dermatitis (AD): A Causal Starting Point for a Personalized (Basic) Therapy
Markus Blaess, Hans-Peter Deigner Focusing on derailed cellular ceramide metabolism fosters recovery of atopic dermatitis lesions and psoriasis plaques
Markus Blaess, Folker Wenzel, Hans-Peter Deigner Recovery of derailed ceramide metabolism in atopic dermatitis: a successful topical off-label use of amitriptyline combined with linoleic acid
Rene Csuk, Hans-Peter Deigner The potential of click reactions for the synthesis of bioactive triterpenes
Mostafa Mahmoud, Stefan Laufer, Hans-Peter Deigner Visual aptamer-based capillary assay for ethanolamine using magnetic particles and strand displacement

2018

Hans-Peter Deigner(Ed.), , Matthias Kohl(Ed.) Precision Medicine: Tools and Quantitative Approaches
Stephan Vilgis, Hans-Peter Deigner Sequencing in Precision Medicine
Lars Kaiser, Julia Weisser, Matthias Kohl, Hans-Peter Deigner Small molecule detection with aptamer based lateral flow assays: Applying aptamer-C-reactive protein cross-recognition for ampicillin detection

2017

Kanan M. Wahedy, Bassam Abu Thaher, Dieter Schollmeyer, Ihab M. Almasri, Rami Y. Morjan, Basem Qeshta, Hans-Peter Deigner Crystal structures of pure 3-(4-bromo-2-chlorophenyl)-1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]triazin-4(3H)-one and contaminated with 3-(4-bromophenyl)-1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]triazin-4(3H)-one
Hans-Peter Deigner, Matthias Kohl, Christoph Ruppert, Sowmya S. Perumbakkam, Lisa Jacob, Anika Schmidt Diagnostische Schnelltests für die personalisierte Medizin
Markus Bläss, Nelly Bibak, Ralf A. Claus, Matthias Kohl, Gabriel A. Bonaterra, Ralf Kinscherf, Stefan Laufer, Hans-Peter Deigner NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation

2016

Bassam Abu Thaher, Dieter Schollmeyer, Basem Qeshta, Kanan M. Wahedy, Ihab M. Almasri, Rami Y. Morjan, Hans-Peter Deigner 1-(Pyridin-4-yl)-3-(2,4,6-trichlorophenyl)benz- [4,5]imidazo[1,2-d ][1,2,4]triazin-4(3H)-one
Bassam Abu Thaher, Dieter Schollmeyer, Basem Qeshta, Hans-Peter Deigner 3-(2,4-Difluorophenyl)-1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]triazin-4(3H)-one
Ha-Yeun Chung, Daniel C. Hupe, Gordon P. Otto, Marcel Sprenger, Alexander C. Bunck, Michael J. Dorer, Clemens L. Bockmeyer, Hans-Peter Deigner, Markus H. Gräler, Ralf A. Claus Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis
Hans-Peter Deigner Bimodal imaging and beyond: Editorial
Basri Gülbakan, Riza Köksal Özgül, Ayse Yüzbasioglu, Matthias Kohl, Hans-Peter Deigner, Meral Özgüc Discovery of biomarkers in rare diseases: innovative approaches by predictive and personalized medicine
Mario Brameshuber, Eva Sevcsik, Benedikt K. Rossboth, Christina Manner, Hans-Peter Deigner, Begüm Peksel, Mária Péter, Zsolt Török, Albin Hermetter, Gerhard J. Schütz Oxidized Phospholipids Inhibit the Formation of Cholesterol-Dependent Plasma Membrane Nanoplatforms

2015

Mostafa Mahmoud, Hans-Peter Deigner Aptamers in Diagnostics: Replacing or Complementing Antibodies?
Markus Bläss, Ralf A. Claus, Hans-Peter Deigner HPLC separation and ultrasensitive optical quantification of ceramide species applying 7-(diethylamino)coumarin-3-carbonyl azide derivatisation
Christoph Ruppert, Matthias Kohl, Lisa Jacob, Hans-Peter Deigner Multiplexing in Bioassays
Markus Bläss, H.P. Le, Ralf A. Claus, Matthias Kohl, Hans-Peter Deigner Stereospecific Induction of Apoptosis in Tumor Cells via Endogenous C16-Ceramide and Distinct Transcripts

2013

Nayla Jbeily, Iris Suckert, Falk A. Gonnert, Benedikt Acht, Clemens L. Bockmeyer, Sascha D. Grossmann, Markus Bläss, Anja Lüth, Hans-Peter Deigner, Michael Bauer, Ralf A. Claus Hyperresponsiveness of mice defi cient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response

2012

Martina Weber, Sandro Lambeck, Nadine Ding, Stefanie Henken, Matthias Kohl, Hans-Peter Deigner, David P. Enot, Ignatius E. Igwe, Lucien Frappart, Michael Kiehntopf, Ralf A. Claus, Thomas Kamradt, Debra Weih, Yoram Vodovotz, David E. Briles, Abiodun D. Ogunniyi, James C. Paton, Ulrich A. Maus, Michael Bauer Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia
Ute Stemmer, Zsuzsanna A. Dunai, Daniel Koller, Gabriel Pürstinger, Elfriede Zenzmaier, Hans-Peter Deigner, Elma Aflaki, Dagmar Kratky, Albin Hermetter Toxicity of oxidized phospholipids in cultured macrophages

2011

Matthias Kohl, S. Koch, Matthias Keller, Hans-Peter Deigner Biochips: Bright Future in Clinical Dx?
Matthias Keller, David P. Enot, Mark P. Hodson, Emeka I. Igwe, Hans-Peter Deigner, Justin Dean, Hayde Bolouri, Hendrik Hagberg, Carina Mallard Inflammatory-Induced Hibernation in the Fetus: Priming of Fetal Sheep Metabolism Correlates with Developmental Brain Injury
Nigel Francis, See Heng Wong, Peter Hampson, Keqing Wang, Stephen P. Young, Hans-Peter Deigner, Michael Salmon, Dagmar Scheel-Toellner, Janet M. Lord Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events
Hans-Peter Deigner, Michael Bauer, Matthias Kohl Method for in vitro diagnosing sepsis utilizing biomarker composed of more than two different types of endogenous biomolecules
Hans-Peter Deigner, Matthias Kohl, Therese Koal, Ignatius E. Igwe, Guido Dallmann, Michael Bauer, David P. Enot Use of bile acids for prediction of an onset of sepsis

2010

Julien B. Landré, Markus Bläss, Matthias Kohl, Tina Schlicksbier, Andriy Ruryk, Ralf Kinscherf, Ralf A. Claus, Albin Hermetter, Matthias Keller, Michael Bauer, Hans-Peter Deigner Addressable bipartite molecular hook (ABMH): Immobilized hairpin probes with sensitivity below 50 fM
Ralf A. Claus, Gordon P. Otto, Hans-Peter Deigner, Michael Bauer Approaching Clinical Reality: Markers for Monitoring Systemic Inflammation and Sepsis
Therese Koal, Hans-Peter Deigner Challenges in Mass Spectrometry Based Targeted Metabolomics
Michael Urban, David P. Enot, Guido Dallmann, Lisa Körner, Verena Forcher, Peter Enoh, Therese Koal, Matthias Keller, Hans-Peter Deigner Complexity and pitfalls of mass spectrometry-based targeted metabolomics in brain research
Hans-Peter Deigner, Ancha Baranova Current Methods and Perspectives in Biomarker Discovery: Editorial
Ronnaug Solberg, David P. Enot, Hans-Peter Deigner, Therese Koal, Sabine Scholl-Bürgi, Ola D. Saugstad, Matthias Keller Metabolomic Analyses of Plasma Reveals New Insights into Asphyxia and Resuscitation in Pigs
Hans-Peter Deigner, Matthias Kohl, Matthias Keller, Therese Koal, Klaus Weinberger Method for In Vitro Diagnosing a Complex Disease
Hans-Peter Deigner, Matthias Kohl, David P. Enot, Therese Koal, Matthias Keller Method for Predicting the Likelihood of an Onset of an Inflammation Associated Organ Failure
Hans-Peter Deigner, Matthias Kohl, Matthias Keller, Therese Koal Method for normalization in metabolomics analysis methods with endogenous reference metabolites
Matthias Keller, Hans-Peter Deigner, David P. Enot, Matthias Kohl, Ronnaug Solberg, Ola D. Saugstad, Therese Koal Method of Diagnosing Asphyxia
Matthias Kohl, Hans-Peter Deigner Preprocessing of gene expression data by optimally robust estimators
William J. Griffiths, Therese Koal, Yuqin Wang, Matthias Kohl, David P. Enot, Hans-Peter Deigner Targeted Metabolomics for Biomarker Discovery
Hans-Peter Deigner, David P. Enot, Matthias Kohl, Ignatius E. Igwe, Therese Koal, Michael Bauer, Guido Dallmann Use of Endogenous Metabolites for Early Diagnosing Sepsis

2009

Johannes Winning, Julia Reichel, Yvonne Eisenhut, Jürg Hamacher, Matthias Kohl, Hans-Peter Deigner, Ralf A. Claus, Michael Bauer, Wolfgang Lösche Anti-platelet drugs and outcome in severe infection: Clinical impact and underlying mechanisms
Ralf A. Claus, Michael J. Dorer, Alexander C. Bunck, Hans-Peter Deigner Inhibition of Sphingomyelin Hydrolysis: Targeting the Lipid Mediator Ceramide as a Key Regulator of Cellular Fate
Salvatore Cuzzocrea, Hans-Peter Deigner, Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Concetta Crisafulli, Rosanna Di Paola, Placido Bramanti, George Matuschak, Daniela Salvemini Inhibition of ceramide biosynthesis ameliorates pathological consequences of spinal cord injury
Hans-Peter Deigner, Matthias Kohl The molecular sepsis signature

2008

Ralf Kinscherf, Hans-Peter Deigner Apoptogenic Signal Transduction in Arteriosclerosis-Associated Cells – Opportunities for Future Therapy?
Hans-Peter Deigner, Albin Hermetter Oxidized phospholipids: emerging lipid mediators in pathophysiology

2007

Gabriel A. Bonaterra, Wulf Hildebrandt, Anne Bodens, Roland Sauer, Klaus A. Dugi, Hans-Peter Deigner, Dan Turcanu, Helmut Heinle, Wulf Dröge, Jürgen Metz, Ralf Kinscherf Increased gene expression of scavenger receptors and proinflammatory markers in peripheral blood mononuclear cells of hyperlipidemic males
Hans-Peter Deigner, E. Gulbins, Ralf A. Claus Sphingolipid Metabolism in Systemic Inflammation

2006

Florian Setzer, Volker Oberle, Markus Bläss, Eva Möller, Stefan Rußwurm, Hans-Peter Deigner, Ralf A. Claus, Michael Bauer, Konrad Reinhart, Wolfgang Lösche Platelet-derived microvesicles induce differential gene expression in monocytic cells: A DNA microarray study
M. Harz, Ralf A. Claus, Clemens L. Bockmeyer, M. Baum, P. Rösch, Karim Kentouche, Hans-Peter Deigner, Jürgen Popp UV-Resonance Raman Spectroscopic Study of Human Plasma of Healthy Donors and Patients with Thrombotic Microangiopathy

2005

Gabriel A. Bonaterra, Wulf Hildebrandt, Anne Bodens, Roland Sauer, Klaus A. Dugi, Hans-Peter Deigner, Wulf Dröge, Jürgen Metz, Ralf Kinscherf Increased cyclooxygenase-2 expression in peripheral blood mononuclear cells of smokers and hyperlipidemic subjects
Ralf A. Claus, Alexander C. Bunck, Clemens L. Bockmeyer, Frank M. Brunkhorst, Wolfgang Lösche, Ralf Kinscherf, Hans-Peter Deigner Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis
Ralf A. Claus, Annette Wüstholz, Stefan Müller, Clemens L. Bockmeyer, Norman H. Riedel, Ralf Kinscherf, Hans-Peter Deigner Synthesis and Antiapoptotic Activity of a Novel Analogue of the Neutral Sphingomyelinase Inhibitor Scyphostatin
Thomas Hilberg, Hans-Peter Deigner, Eva Möller, Ralf A. Claus, Andriy Ruryk, Doreen Gläser, Julien Landre, Frank M. Brunkhorst, Konrad Reinhart, Holger H. Gabriel, Stefan Rußwurm Transcription in response to physical stress - clues to the molecular mechanisms of exercise-induced asthma
Ralf A. Claus, Clemens L. Bockmeyer, Karim Kentouche, Matthias W. Sieber, Volker Oberle, Roland Kaufmann, Hans-Peter Deigner, Wolfgang Lösche Transcriptional regulation of ADAMTS13
V. Tomic, Stefan Rußwurm, Eva Möller, Ralf A. Claus, Markus Bläss, Frank M. Brunkhorst, M. Brügel, K. Bode, F. Bloos, J. Wippermann, T. Wahlers, Hans-Peter Deigner, J. Thiery, Konrad Reinhart, Michael Bauer Transcriptomic and Proteomic Patterns of Systemic Inflammation in On-Pump and Off-Pump Coronary Artery Bypass Grafting

2004

Miroslav Prucha, Andriy Ruryk, Hinnerk Boriss, Eva Möller, Roman Zazula, Ivan Herold, Ralf A. Claus, Konrad Reinhart, Hans-Peter Deigner, Stefan Rußwurm Expression profiling: toward an application in sepsis diagnostics
Alexandra Loidl, Ralf A. Claus, Elisabeth Ingolic, Hans-Peter Deigner, Albin Hermetter Role of ceramide in activation of stress-associated MAP kinases by minimally modified LDL in vascular smooth muscle cells

2003

Ralf Kinscherf, Konstantinos Cafaltzis, Falk Röder, Wulf Hildebrandt, Lutz Edler, Hans-Peter Deigner, Raoul Breitkreutz, Giso Feussner, Jörg Kreuzer, Egon Werle, Gerd Michel, Jürgen Metz, Wulf Dröge Cholesterol levels linked to abnormal plasma thiol concentrations and thiol/disulfide redox status in hyperlipidemic subjects
Ralf Kinscherf, Huse Kamencic, Hans-Peter Deigner, Jürgen Metz Hypercholesterolemia-Induced Long-Term Increase of Macrophages in the Myocardium of New Zealand White Rabbits
Stefan Rußwurm, Hans-Peter Deigner, Konrad Reinhart Microarray technology in sepsis: tool or toy?
Alexandra Loidl, Eva Sevcsik, Gernot Riesenhuber, Hans-Peter Deigner, Albin Hermetter Oxidized Phospholipids in Minimally Modified Low Density Lipoprotein Induce Apoptotic Signaling via Activation of Acid Sphingomyelinase in Arterial Smooth Muscle Cells

2002

Alexandra Loidl, Ralf A. Claus, Hans-Peter Deigner, Albin Hermetter High-precision fluorescence assay for sphingomyelinase activity of isolated enzymes and cell lysates

2001

Hans-Peter Deigner, Ralf A. Claus, Gabriel A. Bonaterra, Christof Gehrke, Nilofar Bibak, Markus Bläss, Michael Cantz, Jürgen Metz, Ralf Kinscherf Ceramide induces aSMase expression: implications for oxLDL-induced apoptosis
Helmut Weicker, Ralf Kinscherf, Karin Diserens, Hans-Peter Deigner, Heiko Strüder Physiology and pathophysiology of basalganglia: impact on motor system function
Stefan Rußwurm, Ilmars Stonans, Elita Stonane, Matthias Wiederhold, Andrea Luber, Peter F. Zipfel, Hans-Peter Deigner, Konrad Reinhart Procalcitonin and CGRP-I mRNA expression in various human tissues
Stefan Rußwurm, Ilmars Stonans, Elita Stonane, Peter F. Zipfel, Hans-Peter Deigner, Konrad Reinhart Various human tissues express procalcitonin and CGRP-I mRNA

2000

Ralf A. Claus, Ralf Kinscherf, Christof Gehrke, Gabriel A. Bonaterra, Purusotam Basnet, Jürgen Metz, Hans-Peter Deigner Antiapoptotic Effects of Propolis Extract and Propol on Human Macrophages Exposed to Minimally Modified Low Density Lipoprotein
Hans-Peter Deigner, Uwe Haberkorn, Ralf Kinscherf Apoptosis modulators in the therapy of neurodegenerative diseases
Ralf A. Claus, Stefan Rußwurm, M. Meisner, Ralf Kinscherf, Hans-Peter Deigner Modulation of the ceramide level, a novel therapeutic concept?

1999

Ralf Kinscherf, Martin Wagner, Huse Kamencic, Gabriel A. Bonaterra, Dongming Hou, Rainer A. Schiele, Hans-Peter Deigner, Jürgen Metz Characterization of apoptotic macrophages in atheromatous tissue of humans and heritable hyperlipidemic rabbits
Ilmars Stonans, Elita Stonane, Stefan Rußwurm, Hans-Peter Deigner, Konrad J. Böhm, Matthias Wiederhold, Lothar Jäger, Konrad Reinhart HepG2 Human Hepatoma Cells Express Multiple Cytokine Genes
Hans-Peter Deigner, Ralf Kinscherf Modulating apoptosis: current applications and prospects for future drug development
Hans-Peter Deigner, Ralf Kinscherf, Ralf A. Claus, Beatrix Fyrnys, Christopher Blencowe, Albin Hermetter Novel reversible, irreversible and fluorescent inhibitors of platelet-activating factor acetylhydrolase as mechanistic probes

1998

Ralf Kinscherf, Ralf A. Claus, Martin Wagner, Christof Gehrke, Huse Kamencic, Dongming Hou, Olaf Nauen, Walther Schmiedt, Gyula Kovacs, Johannes Pill, Jürgen Metz, Hans-Peter Deigner Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent
Walther Schmiedt, Ralf Kinscherf, Hans-Peter Deigner, Huse Kamencic, Olaf Nauen, Juliane Kilo, Hellmut Oelert, Jürgen Metz, Sucharit Bhakdi Complement C6 Deficiency Protects Against Diet-Induced Atherosclerosis in Rabbits

1997

Ralf Kinscherf, Huse Kamencic, Hans-Peter Deigner, Johannes Pill, Walther Schmiedt, Jürgen Metz Der Einfluß von Veränderungen des Blut-Cholesterinspiegels auf Makrophagen im Myokard von Kaninchen
Ralf Kinscherf, Huse Kamencic, Hans-Peter Deigner, Johannes Pill, Walther Schmiedt, Michael Schrader, Jürgen Metz Effect of alterations of blood cholesterol levels on macrophages in the myocardium of New Zealand White rabbits
Ralf Kinscherf, Hans-Peter Deigner, Claus Usinger, Johannes Pill, Martin Wagner, Huse Kamencic, Dongming Hou, Min Chen, Walther Schmiedt, Michael Schrader, Gyula Kovacs, Kanefusa Kato, Jürgen Metz Induction of mitochondrial manganese superoxide dismutase in macrophages by oxidized LDL: its relevance in atherosclerosis of humans and heritable hyperlipidemic rabbits
Ralf Kinscherf, Walther Schmiedt, Huse Kamencic, Hans-Peter Deigner, Johannes Pill, S. Bhakdi, Jürgen Metz Komplement C6-Defizienz führt zu einem signifikant geringeren Anstieg von Makrophagen (CR3/43) und arteriosklerotischen Plaques in Cholesterin-gefütterten Kaninchen
Ralf Kinscherf, Ralf A. Claus, Hans-Peter Deigner, Olaf Nauen, Christoph Gehrke, Albin Hermetter, Stefan Rußwurm, Volker Daniel, Volker Hack, Jürgen Metz Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin-ceramide pathway in human macrophages
Hans-Peter Deigner, Ralf A. Claus, Ralf Kinscherf Modifiziertes LDL als Substratquelle für die Bildung von Ceramid
Beatrix Fyrnys, Ralf A. Claus, Gert Wolf, Hans-Peter Deigner Oxidized Low Density Lipoprotein Stimulates Protein Kinase C (PKC) Activity and Expression of PKC-Isotypes via Prostaglandin-H-Synthase in P388D1 Cells

1996

Ralf A. Claus, Beatrix Fyrnys, Hans-Peter Deigner, Gert Wolf Oxidized Low-Density Lipoprotein Stimulates Protein Kinase C (PKC) and Induces Expression of PKC-Isotypes via Prostaglandin-H-Synthase in P388D1 Macrophage-Like Cells
M. A. Pajares, L. Alvarez, B. Gil Perez, M. L. Martinez Chantar, J. Mingorance, E. Sanchez Gongora, Hans-Peter Deigner, M. Avila, J. M. Mato Regulation and structure of rat liver S-adenosylmethionine synthethase, a target enzyme for studies in liver injury
Hans-Peter Deigner, Ralf A. Claus Stimulation of mitogen activated protein kinase by LDL and oxLDL in human U-937 macrophage-like cells
Hans-Peter Deigner, Ralf A. Claus ox LDL induzierte Tyrosinkinase-Aktivität

1995

Hans-Peter Deigner, Christian E. Freyberg, S. Laufer Distribution and excretion of [14C]-labelled [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5- yl]- [2'-14C]-acetic acid in rats
Christopher Blencowe, Albin Hermetter, Gert M. Kostner, Hans-Peter Deigner Enhanced Association of Platelet-activating Factor Acetylhydrolase with Lipoprotein (a) in Comparison with Low Density Lipoprotein
Hans-Peter Deigner, Christopher Blencowe, Christian E. Freyberg Prevalence of steric restrictions in enzymatic nitrile-hydrolysis of a preparation from Rhodococcus sp. 409
Hans-Peter Deigner, Jose M. Mato, Maria A. Pajares Study of the rat liver S-adenosylmethionine synthetase active site with 8-azido ATP
Beatrix Fyrnys, Christopher Blencowe, Hans-Peter Deigner Susceptibility of phospholipids of oxidizing LDL to enzymatic hydrolysis modulates uptake by P388D1 macrophage-like cells

1994

Hans-Peter Deigner, G. Wolf, U. Ohlenmacher, J. Reichling 1'-Hydroxyeugenol- and coniferyl alcohol derivatives as effective inhibitors of 5-lipoxygenase and Cu(2+)-mediated low density lipoprotein oxidation. Evidence for a dual mechanism
Hans-Peter Deigner, G. Wolf Oxidativ modifiziertes LDL und seine mögliche Rolle in der Atherogenese

1993

Hans-Peter Deigner, Christian E. Freyberg, R. Heck Chemoenzymatic synthesis of carbon-14 labelled antioxidants
Hans-Peter Deigner, Hans A. Dresel Effect of platelet activating factor on the kinetics of LDL oxidation in vitro
Hans-Peter Deigner, Beatrix Fyrnys Synthesis of [32P]labelled 1-O-alkyl-2-desoxy-2-amino-sn′-glycero-3-phosphocholines

1992

Hans-Peter Deigner, Beatrix Fyrnys Rapid synthesis of 2-desoxy-2-amino-3-phosphocholine-glycerinic-acid-alkylester, 1-alkyl-1-desoxy- and 1-O-alkyl-2-desoxy-2-amino-sn-glycero-3-phosphocholines, -3-phospho-N,N′-dimethylethanolamine and -3-phospho-Fmoc-serine-methylester
Hans-Peter Deigner, E. Friedrich, H. Sinn, Hans A. Dresel Scavenging of lipid peroxidation products from oxidizing LDL by albumin alters the plasma half-life of a fraction of oxidized LDL particles

1991

Hans-Peter Deigner Über eine mögliche Rolle von Proteinen bei der LDL-Oxidation

1990

Richard Neidlein, Take Constantinescu, Claus Krieger, Hans-Peter Deigner A Convenient Solid-Support Procedure for the Synthesis of Symmetric Disulphides. The Configuration of Aromatic Carben Atoms in the 1,6-Methano[10]annulene Framework
Hans A. Dresel, Hans-Peter Deigner, J. Frübis, K. Strein, G. Schettler LDL-metabolism of the arterial wall-new implications for atherogenesis

1989

Hans-Peter Deigner, Wing C. Law, Francisco J. Canada, Robert R. Rando Membranes as the energy source in the endergonic transformation of vitamin A to 11-cis-retinols

1988

Richard Neidlein, Hans-Peter Deigner Biotransformation of 4-Oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo-[5.2.1.0 2,6endo]dec-8-en-3on an der Ratte
Richard Neidlein, Hans-Peter Deigner, W. Kramer In vivo- und in vitro-Untersuchung von synthetischem Vergleichsmaterial zu Stoffwechselprodukten von 4-0xa-5-exo-(N-methylcarbamoyloxy-tricyclo[5.2.1.0.2,6endo]dec-8-en-3d-oenr Ratte
Richard Neidlein, Hans-Peter Deigner Pharmakokinetik von 4-oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo-[5:2.1.0. 2,6-endo]dec-8-en-3on an der Ratte