Publications
Werbeck, Nicolas
2020 | |||
| Nicolas D. Werbeck, Vaibhav K. Shukla, Micha B. Kunze, Havva Yalinca, Ruth B. Pritchard, Lucas Siemons, Somnath Mondal, Simon O. Greenwood, John Kirkpatrick, Charles M. Marson, Dennis Flemming Hansen | A distal regulatory region of a class I human histone deacetylase | Nature Communications, 11.2020(Article 3841), 2020 | BibTeX | RIS DOIURN |
| Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Andrea Haegebarth, Antonius ter Laak, Amaury E. Fernandez-Montalvan, Uwe Eberspächer, Nicolas D. Werbeck, Ursula Moenning, Stephan Siegel, Bernard Haendler, Ashley L. Eheim, Carlo Stresemann | Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target | Cancers, 12.2020(1 Article 201), 2020 | BibTeX | RIS DOIURN |
| Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Naomi Barak, Uwe Eberspächer, Nicolas D. Werbeck, Carlo Stresemann, Martin Lange, Ralf Lesche, Nina Zablowsky, Katrin Juenemann, Atanas Kamburov, Laura M. Luh, Thomas M. Leissing, Jeremie Mortier, Michael Steckel, Holger Steuber, Knut Eis, Ashley Eheim, Patrick Steigemann | Identification of Small Molecules that Modulate Mutant p53 Condensation | iScience, 23.2020(9 Article 101517), 2020 | BibTeX | RIS DOIURN |
2019 | |||
| Roman C. Hillig, Brice Sautier, Jens Schroeder, Dieter Moosmayer, Andre Hilpmann, Christian M. Stegmann, Nicolas D. Werbeck, Hans Briem, Ulf Boemer, Joerg Weiske, Volker Badock, Julia Mastouri, Kirstin Petersen, Gerhard Siemeister, Jan D. Kahmann, Dennis Wegener, Niels Böhnke, Knut Eis, Keith Graham, Lars Wortmann, Franz von Nussbaum, Benjamin Bader | Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction | Proceedings of the National Academy of Sciences of the United States of America : PNAS, 116.2019(7), pp. 2551-2560, 2019 | BibTeX | RIS DOIURN |
2016 | |||
| Cathleen Zeymer, Nicolas D. Werbeck, Sabine Zimmermann, Jochen Reinstein, Dennis Flemming Hansen | Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction | Angewandte Chemie : International Edition, 55.2016(38), pp. 11533-11537, 2016 | BibTeX | RIS DOIURN |
2014 | |||
| Cathleen Zeymer, Thomas R. Barends, Nicolas D. Werbeck, Ilme Schlichting, Jochen Reinstein | Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor | Acta Crystallographica Section D Biological Crystallography, 70.2014(2), pp. 582-595, 2014 | BibTeX | RIS DOIURN |
| Nicolas D. Werbeck, Dennis Flemming Hansen | Heteronuclear transverse and longitudinal relaxation in AX4 spin systems: Application to 15N relaxations in 15NH4+ | Journal of Magnetic Resonance, 246.2014(September), pp. 136-148, 2014 | BibTeX | RIS DOIURN |
| Nicolas D. Werbeck, John Kirkpatrick, Jochen Reinstein, Dennis Flemming Hansen | Using 15N‐Ammonium to Characterise and Map Potassium Binding Sites in Proteins by NMR Spectroscopy | ChemBioChem, 15.2014(4), pp. 543-548, 2014 | BibTeX | RIS DOIURN |
2013 | |||
| Micha B. Kunze, David W. Wright, Nicolas D. Werbeck, John Kirkpatrick, Peter V. Coveney, Dennis Flemming Hansen | Loop Interactions and Dynamics Tune the Enzymatic Activity of the Human Histone Deacetylase 8 | Journal of the American Chemical Society, 135.2013(47), pp. 17862-17868, 2013 | BibTeX | RIS DOIURN |
| Nicolas D. Werbeck, John Kirkpatrick, Dennis Flemming Hansen | Probing Arginine Side‐Chains and Their Dynamics with Carbon‐Detected NMR Spectroscopy: Application to the 42 kDa Human Histone Deacetylase 8 at High pH | Angewandte Chemie : International Edition, 52.2013(11), pp. 3145-3147, 2013 | BibTeX | RIS DOIURN |
| Cathleen Zeymer, Nicolas D. Werbeck, Ilme Schlichting, Jochen Reinstein | The Molecular Mechanism of Hsp100 Chaperone Inhibition by the Prion Curing Agent Guanidinium Chloride | Journal of Biological Chemistry, 288.2013(10), pp. 7065-7076, 2013 | BibTeX | RIS DOIURN |
2011 | |||
| Nicolas D. Werbeck, Cathleen Zeymer, Julian N. Kellner, Jochen Reinstein | Coupling of Oligomerization and Nucleotide Binding in the AAA+ Chaperone ClpB | Biochemistry, 50.2011(5), pp. 899-909, 2011 | BibTeX | RIS DOI |
2010 | |||
| Thomas R. Barends, Nicolas D. Werbeck, Jochen Reinstein | Disaggregases in 4 dimensions | Current Opinion in Structural Biology, 20.2010(1), pp. 46-53, 2010 | BibTeX | RIS DOI |
2009 | |||
| Nicolas D. Werbeck, Julian N. Kellner, Thomas R. Barends, Jochen Reinstein | Nucleotide Binding and Allosteric Modulation of the Second AAA+ Domain of ClpB Probed by Transient Kinetic Studies | Biochemistry, 48.2009(30), pp. 7240-7250, 2009 | BibTeX | RIS DOI |
2008 | |||
| Nicolas D. Werbeck, Sandra Schlee, Jochen Reinstein | Coupling and Dynamics of Subunits in the Hexameric AAA+ Chaperone ClpB | Journal of Molecular Biology, 378.2008(1), pp. 178-190, 2008 | BibTeX | RIS DOI |
| Nicolas D. Werbeck, Pamela J. Rowling, Vasuki R. Chellamuthu, Laura S. Itzhaki | Shifting transition states in the unfolding of a large ankyrin repeat protein | Proceedings of the National Academy of Sciences of the United States of America : PNAS, 105.2008(36), pp. 9982-9987, 2008 | BibTeX | RIS DOI |
| Yuki Takayama, Nicolas D. Werbeck, Hirofumi Komori, Kumiko Morita, Kiyoshi Ozawa, Yoshiki Higuchi, Hideo Akutsu | Strategic Roles of Axial Histidines in Structure Formation and Redox Regulation of Tetraheme Cytochrome c3† | Biochemistry, 47.2008(36), pp. 9405-9415, 2008 | BibTeX | RIS DOI |
| Adriane Leskovar, Harald Wegele, Nicolas D. Werbeck, Johannes Buchner, Jochen Reinstein | The ATPase Cycle of the Mitochondrial Hsp90 Analog Trap1 | Journal of Biological Chemistry, 283.2008(17), pp. 11677-11688, 2008 | BibTeX | RIS DOIURN |
2007 | |||
| Nicolas D. Werbeck, Laura S. Itzhaki | Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein | Proceedings of the National Academy of Sciences of the United States of America : PNAS, 104.2007(19), pp. 7863-7868, 2007 | BibTeX | RIS DOI |